3 Ingredients for Hormonal Balance

By Todd Runestad

New functional ingredients are finally delivering for supplement brands the mother of all health solutions for women’s health: hormonal balance. Hormone fluctuations are responsible for the duration and severity of everything from PMS to hot flashes and the range of emotional volatility. 

The botanical of the year is shaping up to be shatavari (Asparagus racemosus). The herb supports healthy signaling across LH/FSH, estradiol, and SHBG to keep estrogen and androgen activity in a favorable range. This balanced tone underpins cycle comfort, clearer skin, and overall hormonal harmony.

When hormones run high, as with women with Polycystic Ovary Syndrome (PCOS)—the leading cause of reproductive failure—shatavari was shown in a 2025 published study on women aged 20-35 to help temper these hormone levels. This led to improved ovarian health, visible physical improvements in hair and skin, and menstrual regularity. 

Yet when hormone levels are low, as with older women in perimenopause, shatavari was shown in a different 2025 study in women aged 40-49 to promote cycle regularity, smoother menopause transitions, and everyday resilience. 

“In PCOS, shatavari lowers hormone levels that are too high. In perimenopause, it supports declining hormone levels,” said Eric Anderson, Managing Director of NXT USA, which markets Xeya Modern Shatavari. “Shatavari is a true hormonal adaptogen.”

Another ingredient aimed at hormone balance is in the biotics category, addressing the neuroendocrine pathways that regulate mood, stress response, and sleep architecture. Verb Biotics’ probiotic strain, LP-815, produces GABA in the gut. This neurotransmitter can improve mood in all its iterations, thus countering one of the effects of hormonal fluctuation. 

A third clinically validated ingredient for hormone harmony is D-glucarate, branded as CelluThrive D-Glucarate, by Applied Food Sciences. The ingredient supports estrogen balance by efficiently removing excess estrogen and xenoestrogens (estrogen mimickers) from the body, promoting more stable shifts in energy, mood, and sleep. 

These ingredients represent a new range of solutions that can help supplement companies deliver for women the confidence and calm they are looking for through the underlying issue of hormonal balance.