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Home » Blogs » WholeFoods Magazine » Can CBD Really Help Manage Stress?

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Drswift

Dr. Sibyl Swift earned her Ph.D. in nutrition and MS in exercise physiology at Texas A&M University and is currently a member of the Board of Directors for cbdMD, Board of Advisors for Harbour Solutions, on the Benchmarking Committee for the Supplement Safety and Compliance Initiative (SSCI) and as co-chair for the Natural Product Associations (NPA) ComPLI Committee. Prior to joining cbdMD, she held roles as Senior VP for Scientific & Regulatory Affairs at the NPA and Associate Director for Research and Strategy within the U.S. Food and Drug Administration’s (FDA) Office of Dietary Supplement Programs.

Can CBD Really Help Manage Stress?

A Science-Based Exploration

June 5, 2025
Sibyl Swift, Ph.D., Chief Science Officer & VP of Regulatory Affairs, cbdMD
Drops of CBD hemp in dropper close-up on blue background
Getty Images

Today’s consumers are navigating more than just busy schedules; they’re coping with unfathomed mental and emotional burdens. 

More than ever, stress management is critical for consumers. According to the American Psychological Association, 75% of Americans reported a physical or mental stress-related symptom the previous month. While traditional remedies like meditation and exercise remain vital, many are turning to cannabidiol (CBD) for its calming, non-psychoactive effects. But what does science actually say?

CBD is a naturally-occurring compound derived from hemp that has been favorably studied as a tool for stress support. A 2023 clinical trial found that adults who took 100 mg of CBD daily experienced notable reductions in tension, irritability, and emotional volatility over a 60-day period.

CBD works primarily through the endocannabinoid system (ECS), a complex network of receptors that help regulate sleep, mood, immunity, and stress. Think of the ECS as your body’s thermostat for stress. When overwhelmed, the ECS helps to support positive emotional regulation by boosting serotonin (the “feel-good” chemical), reducing stress, and enhancing GABA (the brain’s stress brake). While it won’t completely eliminate stress, CBD may help the body cope more effectively with it.

CBD’s anti-inflammatory properties further contribute to its ability to modulate stress. Feeling the effects of stress over long periods of time can promote inflammation which may contribute to more intense feelings of worry, fatigue, and disrupt sleep. Targeting inflammation at the source, CBD can help promote a more adaptive response to stress.

The appeal of CBD lies in its accessibility for everyday consumption. It doesn’t require a prescription, doesn’t produce a high, and is available in a variety of forms that can be integrated into any daily routine.

We studied the safety and benefits of our proprietary, broad spectrum blend. Our data supports the casual consumer starting with around 50 to 100 mg daily and increasing up to 1 mg/pound of body weight based on their preference and overall health. Regardless, we always recommend that consumers speak with a healthcare professional before adding a new supplement to make sure it is right for them. 

Common CBD delivery methods include:

  • Oils: Easy to consume these in drinks and other foods 
  • Capsules: Easy to consume an exact amount
  • Gummies: Fun and easy way to consume CBD

The World Health Organization has identified CBD as generally safe. The most common side effects include fatigue and dry mouth. However, it’s important to note that CBD quality can vary widely; therefore, it’s essential to only use third-party tested products (like cbdMD’s) for purity and potency. 

It’s worth noting that CBD may not be safe if you’re on prescription medication, blood thinners, and are pregnant or breastfeeding. It’s always a good idea to speak to a healthcare professional before adding a new supplement to your daily regimen. By guiding customers toward high-quality, tested products and helping them understand proper usage, natural retailers can play a pivotal role in empowering safe and effective use of CBD.

While CBD may not be a silver bullet, it offers a promising solution to managing everyday stress. Rather than a quick fix, CBD should be viewed as a powerful tool when paired with others known to support mental health such as exercise, a healthy diet, and proper sleep.

CBD’s plant-based, non-psychoactive properties make it an appealing option for those seeking a natural alternative for their health and wellness needs. As research and regulatory frameworks evolve, the CBD market is certain to grow as consumers, practitioners, and retailers navigate the future of wellness.

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NOTE: WholeFoods Magazine is a business-to-business publication. Information on this site should not be considered medical advice or a way to diagnose or treat any disease or illness. Always seek the advice of a medical professional before making lifestyle changes, including taking a dietary supplement. The opinions expressed by contributors and experts quoted in articles are not necessarily those of the publisher or editors of WholeFoods.

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