The finding, according to a press release from Gnosis by Lesaffre: The Quatrefolic group had a higher chance of clinical pregnancy and live birth than those supplementing with only folic acid. The study authors noted that additional prospective studies and randomized clinical trial are needed to determine the effects of folate, vitamin B12, and homocysteine pathway in improving pregnancy outcomes in women after ART. They added, "If our ﬁndings were conﬁrmed, this relatively inexpensive supplementation with vitamin B complex might be considered in clinical practice, particularly in women undergoing ART.”
The study, conducted at the Centre for Assisted Reproductive Technology, Careggi University Hospital in Florence, Italy, looked at 269 caucasian women with an average age of 36.9. There were 111 women that supplemented daily with vitamin B complex (400 µg 5-MTHF, 5 µg vitamin B12, 3 mg vitamin B6) and 158 women who supplemented with only folic acid (400 µg folic acid).