East Windsor, NJ—Sabinsa announced that its branded ingredient Curcumin C3 Complex is the subject of two recently published clinical trials that explored the uses of C3 Complex to support healthy aging.
Effects of Curcumin C3 Complex on Physical Function in Moderately Functioning Older Adults with Low-Grade Inflammation — A Pilot Trial was published in the Journal of Frailty & Aging. Researchers investigated the effects of C3 Complex for improving physical function and muscle strength in older adults. Key findings: C3 Complex 1000 mg/day, along with Sabinsa’s bioavailability enhancer Bioperine, increased knee extension and flexion peak torque compared to placebo group. Sabinsa said the benefits are attributed to larger improvement in physical function and lower-limb muscle strength improvement. The authors hypothesize that muscle strength improvements may be related to the anti-inflammatory effects of C3 Complex. No treatment-related side effects were reported, which Sabinsa noted is especially relevant considering the participants average age of 79.4 years.
The researchers concluded: "This pilot trial suggests that there were no difficulties with recruitment, adherence and safety specific to the study protocol. Preliminary findings warrant a Phase IIb clinical trial to test the effect of Curcumin C3 Complex on physical function and muscle strength in older adults at risk for mobility disability."
The second paper, Bioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women, was published in Nutrients. Sabinsa noted that a decrease of estrogen in menopause leads to increased body mass index, elevated systemic inflammation, and metabolic disturbances. This randomized crossover study had a minimum one-week washout period. Overweight or obese postmenopausal women were given bioactive yogurt containing C3 Complex and chlorogenic acid. The key finding: The level of inflammatory marker TNFα came down immediately after consumption of C3 Complex/chlorogenic acid containing yogurt, Sabinsa reported, noted that this shows the acute nature of the effect. Sabinsa explained that TNFα may be involved as a low-grade stimulus of osteoporosis and metabolic dysfunctions arising out of estrogen deficiency. Higher amount of the actives in the functional food could have more pronounced effects, the researchers hypothesized.
“The aging population needs supplements to help them stay healthy and socially active,” remarked Dr. Muhammed Majeed, the Founder and Chairman of Sabinsa Corporation. “It is gratifying to see benefits of C3 Complex identified by these studies showing it may specifically support the health of older people.”