Alzheimer’s disease is marked by progressive deficit in memory and cognitive ability, the press release explains, but the damage caused by the disease is not confined to the central nervous system. Alzheimer’s can also cause damage to organs including the spleen, liver, lungs, kidneys, and brain stem, all of which is what makes Alzheimer’s ultimately fatal.
The study in question,published in Antioxidants,was conducted on male and female mice at the Field Neurosciences Institute, Central Michigan University, and investigated how the curcuminoid formulation Curcugreen can help prevent abnormalities in peripheral organs of those suffering from Alzheimer’s disease.
In the study, the mice received the equivalent of 100mg/kg of Curcugreen for two months. Cellular changes in the spleen, liver, kidneys, and lungs were investigated for cell death, amyloid deposition, pTau levels (markers of Alzheimer’s), pro- and anti-inflammatory markers, and overall cell death/survival markers.
The researchers found that Curcugreen reduced enlargement and degeneration of the spleen, inflammation in the kidney, lung damage, and damage to the liver, including enlargement of liver cells and inflammation of the central hepatic vein. The results also showed a reduction in cell death in all areas. Plus, in the brain, Curcugreen also decreased amyloid deposition, pTau, cell loss, and inflammatory markers.
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“We are encouraged by this suggestion that curcumin could help protect against secondary organ stress and cellular damage, and help against overall damage wrought by this undiscriminating disease,” said Benny Antony, Ph.D., Joint Managing Director for Arjuna and inventor of Curcugreen (BCM-95), in the press release.Part of what made the results possible, according to the press release, is Curcugreen’s high bioavailability: The formulation has been shown to achieve levels of free curcumin about 200 to 300 times higher in the blood, brain, liver, and kidneys than levels reported for natural curcumin in other studies.
“Cognitive health is emerging as one of the more serious health issues facing an aging population,” Antony added. “But in the case of Alzheimer’s disease, the co-morbid damage to the rest of the body’s critical structures raises the stakes of prevention and mitigation quite literally to life or death status. At Arjuna, we believe that maintaining physical brain and body health naturally through safe and effective plant-based ingredients is a game-changer. Our highly bioavailable turmeric extract can be an important weapon in the campaign against this devastating, yet widely prevalent, disease.”
