“Based on the evidence reviewed, the botanical material bitter orange peel, at the doses typically used in herbal medicine and food, is not considered to pose any risk to the health of consumers.” This is the finding of “Synephrine, Octopamine and Caffeine Health Risk Assessment Report,” prepared by Robin Marles, Ph.D., Director, Bureau of Clinical Trials and Health Sciences, Natural Health Products Directorate (NHPD) of Heath Canada. Health Canada is the Canadian counterpart to the U. S. Food and Drug Administration.