Bethesda, MD—National Institutes of Health researchers have identified how resveratrol may confer its health benefits. Resveratrol is a naturally occurring chemical found in plants like grapes. The researchers found that resveratrol does not directly activate sirtuin 1, a protein associated with aging. Instead, it inhibits phosphodiesterases (PDEs), proteins that help regulate cell energy. The chemical has gained some interest from pharmaceutical companies for its potential to fight diabetes, inflammation and cancer.